Key result
FDG PET/CT visual assessment yielded 74% sensitivity and 91% specificity for prosthetic heart valve endocarditis, which improved to 91% and 95% after excluding significant confounders.
Why the study?
Does visual and quantitative assessment of 18F-FDG PET/CT provide high diagnostic accuracy for prosthetic heart valve endocarditis when accounting for confounders?
Observational (n=237)
Blinded to clinical data
Yes
Does visual and quantitative assessment of 18F-FDG PET/CT provide high diagnostic accuracy for prosthetic heart valve endocarditis when accounting for confounders?
FDG PET/CT demonstrates high diagnostic accuracy for prosthetic heart valve endocarditis, particularly when performed early to avoid confounding by low inflammatory activity and when accounting for the use of surgical adhesives.
No takes yet. Share an insight, caveat, or question.
Standardized FDG PET/CT protocols may aid PVE diagnosis; hypothesis-generating and requires prospective validation.
Swart et al. (2018) conducted an observational in Prosthetic heart valve endocarditis (n=237). 18F-FDG PET/CT vs. FDG PET/CT for other indications (negative control) was evaluated on Diagnostic accuracy (sensitivity, specificity, PPV, NPV) for prosthetic heart valve endocarditis. FDG PET/CT visual assessment yielded 74% sensitivity and 91% specificity for prosthetic heart valve endocarditis, which improved to 91% and 95% after excluding significant confounders.
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