Key result
Right hemisphere inactivation during the intracarotid sodium amobarbital test caused a greater increase in heart rate and significant decrease in parasympathetic tone compared to left inactivation.
Why the study?
Does right versus left hemisphere inactivation during the intracarotid sodium amobarbital test differentially affect heart rate and heart rate variability?
Observational (n=73)
Does right versus left hemisphere inactivation during the intracarotid sodium amobarbital test differentially affect heart rate and heart rate variability?
The right cerebral hemisphere appears to have a greater role in the regulation of cardiac function, specifically through the modification of parasympathetic effects.
Right-hemisphere inactivation during Wada testing alters HR/HRV more than left; leaves open hemispheric lateralization hypotheses for autonomic regulation in epilepsy.
PURPOSE: Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re-investigate this topic with a larger N than has heretofore been used. METHODS: The electrocardiogram was recorded during left and right ISAs in 73 subjects. Raw heart rate and heart rate variability were calculated. RESULTS: Raw heart rate increased during inactivation of either hemisphere, but more so for the right hemisphere. Heart rate variability changes consistent with decreasing parasympathetic tone also were found to occur during either ISA, but to a significant degree, only during right ISA. CONCLUSIONS: The right hemisphere appears to have a greater role in cerebral regulation of cardiac function, perhaps by virtue of the modification of parasympathetic effects.
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Ahern et al. (2001) reported an observational. Right intracarotid sodium amobarbital (ISA) vs. Left intracarotid sodium amobarbital (ISA) was evaluated on Heart rate and heart rate variability. Right hemisphere inactivation during the intracarotid sodium amobarbital test caused a greater increase in heart rate and significant decrease in parasympathetic tone compared to left inactivation.
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