Diabetic ketoacidosis was associated with significantly higher cardiac troponin I levels at admission compared to healthy controls (0.193 vs 0.176 ng/dl; p<0.001).
Case-Control (n=38)
Is acute diabetic ketoacidosis associated with myocardial injury as measured by cardiac biomarkers?
Severe diabetic ketoacidosis is associated with transient elevations in cardiac biomarkers, suggesting a reversible detrimental effect on the myocardium.
Absolute Event Rate: 0.193% vs 0.176%
p-value: p=<0.001
OBJECTIVE: To examine the hypothesis that diabetic ketoacidosis may be associated with some degree of induced injury to heart muscle, related either to acidosis or hyperglycemia. METHODS: Nineteen diabetic patients with acute ketoacidosis and 19 healthy children were enrolled in this study. Cardiac troponin I (cTnI), creatine kinase (CK)-MB and myoglobin levels were analyzed soon after admission and after 24 h. Patients were subdivided into two groups according to blood pH. RESULTS: At the time of admission, the diabetic patients had significantly higher values than the controls for cTnI (0.193+/-0.008 vs 0.176+/-0.006 ng/dl; p or =7.0 and patients with pH <7.0. In addition, serum cTnI levels correlated negatively with blood pH (r = -0.57, p = 0.026) and HCO3- (r = -0.65, p = 0.008) in the patients with diabetic ketoacidosis on admission. CONCLUSION: Our findings suggest that diabetic ketoacidosis, particularly when severe, has a detrimental effect on the myocardium.
Atabek et al. (Thu,) conducted a case-control in Diabetic ketoacidosis (n=38). Diabetic ketoacidosis vs. Healthy children was evaluated on Cardiac troponin I (cTnI) at admission (p=<0.001). Diabetic ketoacidosis was associated with significantly higher cardiac troponin I levels at admission compared to healthy controls (0.193 vs 0.176 ng/dl; p<0.001).