Key result
Diabetic ketoacidosis was associated with significantly higher cardiac troponin I levels at admission compared to healthy controls (0.193 vs 0.176 ng/dl; p<0.001).
Why the study?
Is acute diabetic ketoacidosis associated with myocardial injury as measured by cardiac biomarkers?
Population
19 diabetic patients with acute ketoacidosis and 19 healthy children
Comparison
Acute diabetic ketoacidosis vs Healthy children
Design
Case-control
Follow-up
24 hours
Authors
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May indicate myocardial stress in pediatric DKA; hypothesis-generating and requires prospective confirmation before clinical adoption.
Case-Control (n=38)
Is acute diabetic ketoacidosis associated with myocardial injury as measured by cardiac biomarkers?
Absolute Event Rate: 0.193% vs 0.176%
p-value: p=<0.001
Severe diabetic ketoacidosis is associated with transient elevations in cardiac biomarkers, suggesting a reversible detrimental effect on the myocardium.
Atabek et al. (2004) conducted a case-control in Diabetic ketoacidosis (n=38). Diabetic ketoacidosis vs. Healthy children was evaluated on Cardiac troponin I (cTnI) at admission (p=<0.001). Diabetic ketoacidosis was associated with significantly higher cardiac troponin I levels at admission compared to healthy controls (0.193 vs 0.176 ng/dl; p<0.001).
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