Recent aspirin use is associated with smaller myocardial infarct size and lower likelihood of Q-wave infarction
Key result
Recent aspirin use before acute myocardial infarction was associated with a lower likelihood of Q-wave infarction compared to nonusers (adjusted OR 0.77; 95% CI 0.61-0.97; P=0.03).
Why the study?
Does recent aspirin use reduce infarct size and the likelihood of Q-wave infarction in patients with acute myocardial infarction who do not receive thrombolytic therapy?
Population
2,206 patients with acute myocardial infarction who did not receive thrombolytic therapy.
Comparison
Aspirin use in the 4 days before myocardial… vs No aspirin use in the 4 days before myocardial…
Design
Cohort
Authors
Discussion
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Implication
Recent aspirin use may limit infarct size; leaves open whether pre-MI aspirin improves outcomes in observational cohorts.
Study Design
Type
Observational (n=3,665)
Structured PICO
Does recent aspirin use reduce infarct size and the likelihood of Q-wave infarction in patients with acute myocardial infarction who do not receive thrombolytic therapy?
P
Population
3,665 patients with acute myocardial infarction, with analysis focused on 2,206 who did not receive thrombolytic therapy, to assess the impact of recent aspirin use.
E
Exposure
Aspirin use in the 4 days before myocardial infarction
C
Comparator
No aspirin use in the 4 days before myocardial infarction
O
Outcome
Infarct size (assessed by peak creatine kinase levels) and likelihood of Q-wave infarction (assessed by electrocardiographic interpretations)surrogate
Main Result
Odds Ratio: 0.77 (95% CI 0.61–0.97)
Absolute Event Rate: 38.9% vs 48.7%
p-value: p=0.03
Recent aspirin use prior to acute myocardial infarction is associated with smaller infarct size and a lower likelihood of Q-wave infarction in patients not receiving thrombolytic therapy.
Cite This Study
Mukamal et al. (1999) conducted an observational in acute myocardial infarction (n=3,665). Recent aspirin use vs. Nonusers was evaluated on Q-wave infarction (adjusted OR 0.77, 95% CI 0.61 to 0.97, p=0.03). Recent aspirin use before acute myocardial infarction was associated with a lower likelihood of Q-wave infarction compared to nonusers (adjusted OR 0.77; 95% CI 0.61-0.97; P=0.03).