Key result
Pre-hospital aspirin administration in ST-elevation myocardial infarction was associated with significantly lower 7-day mortality compared to post-admission administration (2.4% vs 7.3%; OR 0.43).
Why the study?
Does pre-hospital aspirin administration improve survival in patients with ST-segment elevation AMI?
Population
922 consecutive acute myocardial infarction patients with ST-segment elevation in Killip class I-III on…
Comparison
Pre-hospital administration of aspirin vs Aspirin administration after hospital admission
Design
Cohort
Follow-up
30 days
Authors
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May support pre-hospital aspirin in STEMI; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=922)
Does pre-hospital aspirin administration improve survival in patients with ST-segment elevation AMI?
Odds Ratio: 0.43 (95% CI 0.18–0.92)
Absolute Event Rate: 2.4% vs 7.3%
p-value: p=0.002
Pre-hospital administration of aspirin in patients with ST-segment elevation myocardial infarction is associated with improved short-term survival compared to in-hospital administration.
Barbash et al. (2002) conducted a cohort in Acute myocardial infarction with ST-segment elevation (n=922). Pre-hospital aspirin administration vs. Aspirin administration after hospital admission was evaluated on 7-day mortality (OR 0.43, 95% CI 0.18-0.92, p=0.002). Pre-hospital aspirin administration in ST-elevation myocardial infarction was associated with significantly lower 7-day mortality compared to post-admission administration (2.4% vs 7.3%; OR 0.43).
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