Key result
Interspecies variations in ventricular electrophysiological properties were inversely correlated with O2 consumption (r = -0.78 to -0.92) and altered by experimental thyroid state modification.
Interspecies variations in ventricular electrophysiological properties correlate with thyroid state, which modulates action potential duration and amplitude.
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Species differences in ventricular repolarization warrant caution in translational models; leaves open thyroid state's role in AP variation across mammals.
Binah et al. (1987) studied this question. Thyroid state modification (thyroxine or propylthiouracil) and interspecies O2 consumption was evaluated on Ventricular action potential characteristics (resting membrane potential, AP amplitude, duration, and area). Interspecies variations in ventricular electrophysiological properties were inversely correlated with O2 consumption (r = -0.78 to -0.92) and altered by experimental thyroid state modification.
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