Diabetic Neuropathy Presenting as the Initial Clinical Manifestation of Diabetes

Article1 September 1958DIABETIC NEUROPATHY PRESENTING AS THE INITIAL CLINICAL MANIFESTATION OF DIABETESMAX ELLENBERG, M.D., F.A.C.P.MAX ELLENBERG, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-620 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeuropathy occurring in association with diabetes mellitus presents many obscure features. The etiology, pathology and therapy are essentially unknown, and the diagnosis itself is one of exclusion and beset with many pitfalls.1 One of the few areas in this perplexing field that has won wide acceptance by many leading authorities is that the neuropathy follows a prolonged period of poor diabetic control.2-6 This view, however, is inconsistent with recorded observations of neuropathy actually preceding or accompanying the onset of any clinical manifestations of diabetes.Diabetic neuropathy antedating the clinical appearance of diabetes mellitus has been recorded, frequently as an incidental...Bibliography1. Ellenberg M: Diabetic neuropathy: pitfalls in diagnosis, Arch. Int. Med. 100: 906, 1957. CrossrefGoogle Scholar2. JoslinRootWhiteMarbleBailey EPHFPACC: The treatment of diabetes mellitus, 8th Ed., 1946, Lea and Febiger, Philadelphia. Google Scholar3. Rundles RW: Diabetic neuropathy, Bull. New York Acad. Med. 26: 598, 1950. MedlineGoogle Scholar4. 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Sprague RG, in discussion of Treusch, J. V.: Diabetic neuritis: a tentative working classification, Proc. Staff Meet., Mayo Clin. 20: 393, 1945. Google Scholar14. Rudy A: Diabetic neuropathy, New England J. Med. 233: 684, 1945. CrossrefMedlineGoogle Scholar15. LincoffCogan HADG: Unilateral headache and oculomotor paralysis not caused by aneurysm, Arch. Ophth. 57: 181, 1957. CrossrefMedlineGoogle Scholar16. Garland H: Diabetic amyotrophy, Brit. M. J. 2: 1287, 1955. CrossrefMedlineGoogle Scholar17. RootRogers HFMH: Diabetic neuritis with paralysis, New England J. Med. 202: 1049, 1930. CrossrefGoogle Scholar18. Jackson WP: Further studies in prediabetes, Lancet 1: 614, 1957. CrossrefGoogle Scholar19. Hoet JP: Carbohydrate metabolism during pregnancy, Diabetes 3: 1, 1954. CrossrefMedlineGoogle Scholar20. Dolger H: Clinical evaluation of vascular damage in diabetes mellitus, J. A. M. A. 134: 1289, 1947. CrossrefMedlineGoogle Scholar21. Wagener HP: Retinopathy in diabetes mellitus, Proc. Am. Diabetes A. 5: 203, 1945. Google Scholar22. Freedman LR: Inapparent diabetes mellitus as a cause of renal insufficiency due to Kimmelstiel-Wilson lesions, Bull. Johns Hopkins Hosp. 100: 132, 1957. MedlineGoogle Scholar23. Ditzel J: Morphologic and hemodynamic changes in the smaller blood vessels in diabetes mellitus. II. The degenerative and hemodynamic changes in the bulbar conjunctiva of normotensive diabetic patients, New England J. Med. 250: 587, 1954. CrossrefMedlineGoogle Scholar24. DryHines TJEA: The role of diabetes in the development of degenerative vascular disease: with special reference to the incidence of retinitis and peripheral neuritis, Ann. Int. Med. 14: 1893, 1941. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MAX ELLENBERG, M.D., F.A.C.P.Affiliations: New York, N. Y.*Received for publication October 23, 1957.From the Department of Medicine, The Mount Sinai Hospital, New York, N. Y.Requests for reprints should be addressed to Max Ellenberg, M.D., 45 East Sixty-sixth Street, New York 21, N. Y. 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KOZAK, M.D., F.A.C.P.Neuropathie diabetique avec atteinte severe du systeme autonomeDIABETES MELLITUSÜber den Einfluß zusätzlicher Noxen auf Neuritis und Polyneuritis bei latentem Diabetes mellitusEtiologic Considerations in Peripheral Vascular Diseases of the Lower Extremity with Special Reference to Diabetes MellitusSerum Lipids and Glucose Tolerance in Subjects with a Family History of Diabetes MellitusIl concetto clinico di prediabeteTHE PSEUDOTABES SYNDROME IN DIABETESSelected Problems in Endocrine MedicineA non-atheromatous proliferative vascular lesion of the retina in diabetes mellitusDIABETIC NEUROPATHY: A CONSIDERATION OF FACTORS IN ONSET*MAX ELLENBERG, M.D., F.A.C.P.DIABETIC NEUROPATHY: EVALUATION OF FACTORS IN ONSET 1 September 1958Volume 49, Issue 3 Page: 620-631 Keywords Clinical pathology Diabetes mellitus Etiology Hospital medicine Hyperglycemia Neuropathy ePublished: 1 December 2008 Issue Published: 1 September 1958 PDF downloadLoading ...