Key result
In volume-overloaded rabbit hearts, the conversion from 9MPA to 3MNA by beta-oxidation was faster than in sham-control hearts (P<0.05), without changes in PPARalpha protein expression.
p-value: p=<0.05
Myocardial fatty acid metabolism is enhanced in eccentric cardiac hypertrophy induced by volume-overload, without changes in protein expressions of PPARalpha and fatty acid utilization enzymes.
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Hypothesis-generating for metabolic remodeling in volume-overload; leaves open whether PPARα-targeted interventions alter clinical outcomes.
Miyamoto et al. (2004) studied Volume-overloaded hearts (eccentric cardiac hypertrophy). Volume-overload (carotid-jugular shunt formation) vs. Sham-operated rabbits was evaluated on Conversion from 9MPA to 3MNA by beta-oxidation (p=<0.05). In volume-overloaded rabbit hearts, the conversion from 9MPA to 3MNA by beta-oxidation was faster than in sham-control hearts (P<0.05), without changes in PPARalpha protein expression.
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