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February 1, 2003Journal of Applied Physiology

Characterization of cardiac hypertrophy and heart failure due to volume overload in the rat

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Key result

Volume overload induced by aortocaval shunt in rats led to decompensated hypertrophy and heart failure by 8-16 weeks, uniquely characterized by upregulated beta-adrenoceptor signal transduction.

Population

Sprague-Dawley rats

Design

Preclinical

Follow-up

16 weeks

Authors

XWXi WangArmy Medical UniversityBRBin RenSouthwest Jiaotong UniversitySLSongyan LiuJilin University

Discussion

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Overview

Hypothesis-generating for volume-overload hypertrophy stages in rats; leaves open translation to human heart failure.

Structured PICO

P
Population
Sprague-Dawley rats evaluated at 1, 2, 4, 8, and 16 weeks after aortocaval fistula induction.
I
Intervention
Aortocaval fistula (shunt) induced by needle technique
O
Outcome
Alterations in general characteristics, morphology of the heart, hemodynamics, myosin heavy chain isoforms, and beta-adrenoceptor responsivenesssurrogate

Volume overload-induced heart failure in rats is uniquely characterized by an upregulation of beta-adrenoceptor signal transduction, contrasting with typical downregulation seen in other heart failure models.

Cite This Study

Wang et al. (2003) studied Cardiac hypertrophy and heart failure due to volume overload. Aortocaval fistula (shunt) was evaluated on Alterations in general characteristics, morphology, hemodynamics, myosin heavy chain isoforms, and beta-adrenoceptor responsiveness. Volume overload induced by aortocaval shunt in rats led to decompensated hypertrophy and heart failure by 8-16 weeks, uniquely characterized by upregulated beta-adrenoceptor signal transduction.

synapsesocial.com/papers/6a6ae2b001245da06ecb53d8https://doi.org/10.1152/japplphysiol.00248.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 2. Long-term effects.1991 · 78 citations
  2. 2Adaptational changes of MHC gene expression and isozyme transition in cardiac overloading1991 · 44 citations
  3. 3Changes in collagenase and collagen gene expression after induction of aortocaval fistula in rats2001 · 36 citations
  4. 4Signaling Pathways for Cardiac Hypertrophy and Failure1999 · 874 citations
  5. 5Congestive heart failure secondary to an arteriovenous fistula from cardiac catheterization and angioplasty1991 · 16 citations