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July 30, 2026Infection and ImmunityOpen Access

Protein kinase F regulates the virulence of Mycobacterium tuberculosis

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Authors

FTFlor Torres-JuárezSRShivangi RastogiDYDavid C. Young

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Overview

Randomized trial demonstrates the role of PknF in modulating virulence in mice, suggesting implications for treatment strategies.

Key Points

  • This research aims to elucidate the role of protein kinase F (PknF) in the virulence of Mycobacterium tuberculosis in vivo.
  • Generated a pknF deletion mutant (∆pknF) of Mycobacterium tuberculosis CDC1551.
  • Compared growth rates of ∆pknF, complemented strains, and wild type in murine lungs over days 28 and 90-98.
  • Assessed NLRP3-inflammasome activation and inflammation in infected lung sections.
  • ∆pknF strain exhibited a 100-fold increase in growth at day 28 compared to wild type and complemented strains.
  • Increased pulmonary bacterial loads were noted in ∆pknF infected mice, regardless of Nlrp3 status.
  • Infection with ∆pknF resulted in decreased survival in highly susceptible mice compared to complemented strain.

Cite This Study

Torres-Juárez et al. (2026) studied this question.

synapsesocial.com/papers/6a6af4ad60e2b924d3ea02eehttps://doi.org/10.1128/iai.00698-25
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