Key result
Endothelial dysfunction, characterized by reduced nitric oxide bioavailability and eNOS uncoupling, contributes to the pathogenesis and worsening of cardiovascular and endocrine-metabolic diseases.
Design
Review
Authors
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Supports endothelial dysfunction as therapeutic target; leaves open interventional trials before clinical adoption.
Endothelial dysfunction, driven by mechanisms such as reduced nitric oxide bioavailability and eNOS uncoupling, plays a critical role in the pathogenesis and progression of cardiovascular and endocrine-metabolic diseases.
Davel et al. (2011) conducted a review in Cardiovascular and endocrine-metabolic diseases. Endothelial dysfunction was evaluated. Endothelial dysfunction, characterized by reduced nitric oxide bioavailability and eNOS uncoupling, contributes to the pathogenesis and worsening of cardiovascular and endocrine-metabolic diseases.
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