What question did this study set out to answer?

To synthesize selenium-containing heterocycles with tertiary amine functionalities and evaluate their biological activities.

Novel Tertiary Amine‐Functionalized Selenium Heterocycles: Synthesis, Antibacterial, and Antioxidant Investigations

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Novel selenium-containing heterocycles exhibit antibacterial and antioxidant properties, suggesting pharmaceutical potential.

To synthesize selenium-containing heterocycles with tertiary amine functionalities and evaluate their biological activities.
Synthesis of three series of selenium-containing heterocycles through reactions involving selenium-chloroacetamide scaffold derivatives and secondary amines.
Assessment of antibacterial activity against Gram-positive and Gram-negative bacterial strains, particularly Bacillus cereus.
Evaluation of antioxidant activity compared to vitamin C.
Compounds with diethylamino and piperidine moieties demonstrated enhanced antibacterial activity against Bacillus cereus, surpassing the standard drug ciprofloxacin.
Compound 5b exhibited antioxidant activity comparable to vitamin C, with an inhibition percentage of 74%.
Derivatives 6a and 7a showed high antioxidant properties with inhibition rates of 72% and 67%, respectively.

Hussein et al. (2026) studied this question.

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