What question did this study set out to answer?

This study aims to understand the functional differences between GC-derived and GC-independent memory B cells in mice.

GC-independent B cells contribute to durable humoral responses and protection in mice 2309338

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Randomized trial investigates GC-independent B cells' role in long-term immune responses in mice, suggesting new vaccine strategies.

This study aims to understand the functional differences between GC-derived and GC-independent memory B cells in mice.
Memory B cells were sorted from Bcl6fl/fl and Bcl6fl/flCD4Cre mice and analyzed using single-cell RNA sequencing.
B cells were transferred to Rag2ko mice and tracked for up to 6 months post immunization with specific antigens.
Responses to homologous and sub-heterotypic influenza viruses were assessed after immunization.
Four GC-independent and two GC-dependent B cell clusters were identified, with GC B cells depleted without germinal centers.
GC and non-GC antigen-experienced resting B cells were reactivated upon reencountering the same antigen, generating new germinal centers.
Non-GC B cell responses provided protection against both homologous and heterologous influenza strains after immunization.

Pillai et al. (2026) studied this question.

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