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This research aims to understand how different secondary lymphoid organs (SLOs) influence the behavior and differentiation of lymphocytes in humans.

Tissue-specific regulation of human secondary lymphoid organ responses: a systems approach 2307169

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This research aims to understand how different secondary lymphoid organs (SLOs) influence the behavior and differentiation of lymphocytes in humans.
Profiles of SLO immune cell subtypes were analyzed in human PBMCs and matched lymph nodes using a 39-plex CyTOF panel.
Screened expression of 345 protein antigens in 6 SLO regions including spleen and pancreatic lymph nodes (pancLN).
Observed consistent patterns of CD69+ T cells across naïve, effector, and memory subsets in pancLNs.
CD69+ T cells exhibited distinct proteomic characteristics compared to CD69- T cells within the same subset.
Identified tissue-specific expression of protein antigens among phenotypically similar immune subsets.

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Randomized trial investigates lymphocyte behavior in secondary lymphoid organs, suggesting tissue-specific immune activation profiles.

Khan et al. (2026) studied this question.

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