Sıçanlarda Lambda-Sihalotrin Kaynaklı Gastrointestinal Hasar Üzerine Karvakrol’ün Etkilerinin İncelenmesi: Apoptoz ve Endoplazmik Retikulum Stresi Yolaklarının Düzenlenmesi

July 28, 2026Van veterinary journalOpen Access

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Key Points

This study aims to explore the mechanisms related to gastrointestinal damage caused by lambda-sihalotrin and evaluate the protective effects of carvacrol.
Five groups of male Sprague-Dawley rats were formed: healthy control, carvacrol, lambda-sihalotrin, lambda-sihalotrin+carvacrol 25 mg/kg, and lambda-sihalotrin+carvacrol 50 mg/kg.
The treatments were administered orally for 21 days.
Assessments included levels of malondialdehit, glutatyon peroksidaz, and süperoksit dismutaz activities.
In the lambda-sihalotrin group, malondialdehit levels significantly increased.
Glutatyon peroksidaz and süperoksit dismutaz activities, along with glutatyon levels, were significantly reduced (p<0.05).
Carvacrol showed protective effects against the oxidative damage caused by lambda-sihalotrin.

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Investigates carvacrol's protective effect against gastrointestinal damage in rats, suggesting potential therapeutic benefits.

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Bozkurt et al. (2026) studied this question.

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