What does this research mean for the field?

High C-reactive protein/albumin ratio (CAR) and neutrophil-lymphocyte ratio (NLR) are associated with poor functional outcomes and serve as independent prognostic indicators in patients with aneurysmal subarachnoid hemorrhage undergoing microsurgical clipping. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association between early inflammatory and nutritional biomarkers and functional outcomes in patients undergoing microsurgical clipping for aneurysmal subarachnoid hemorrhage.

September 2, 2026Medical Journal of Western Black SeaOpen Access

Anevrizmal subaraknoid kanamada inflamasyon–nutrisyon profili ve fonksiyonel sonuçlar: Tek merkezli retrospektif kohort çalışması

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Authors

AAAyşegül Esen AydınBakırköy Psychiatric Hospital EİErcan İvgenErgani Devlet Hastanesi ESEren SogukIstanbul University-Cerrahpaşa

Discussion

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Implication

Cohort study reveals high C-reactive protein-to-albumin ratio predicts poor functional recovery after aneurysmal subarachnoid hemorrhage clipping, highlighting early biomarker utility.

Key Points

To evaluate the association between early inflammatory and nutritional biomarkers and functional outcomes in patients undergoing microsurgical clipping for aneurysmal subarachnoid hemorrhage.
Retrospective single-center cohort study evaluating 73 patients undergoing microsurgical clipping for aneurysmal subarachnoid hemorrhage between January 2021 and December 2025.
Collected admission demographics, clinical scales, and laboratory data within 24 hours of admission to compute NLR, SII, SIRI, CAR, and PNI.
Assessed functional outcomes based on the modified Rankin Scale (mRS) and evaluated predictors using multivariable and ROC analyses.
Patients with poor functional outcomes showed significantly higher CAR (p=0.010) and borderline higher NLR (p=0.050), whereas differences in SII (p=0.096), SIRI (p=0.081), and PNI did not reach statistical significance.
Multivariate analysis identified advanced age, high WFNS score, and elevated CAR as independent predictors of poor functional outcome, with CAR exhibiting the highest discriminative performance on ROC analysis.

Cite This Study

Aydın et al. (2026) studied this question.

synapsesocial.com/papers/6a97e275c562ede874ec6916 https://doi.org/10.29058/mjwbs.1963622

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Implication

Cohort study reveals high C-reactive protein-to-albumin ratio predicts poor functional recovery after aneurysmal subarachnoid hemorrhage clipping, highlighting early biomarker utility.

Anevrizmal subaraknoid kanamada inflamasyon–nutrisyon profili ve fonksiyonel sonuçlar: Tek merkezli retrospektif kohort çalışması

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Key Points

Cite This Study

Anevrizmal subaraknoid kanamada inflamasyon–nutrisyon profili ve fonksiyonel sonuçlar: Tek merkezli retrospektif kohort çalışması

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Key Points

Cite This Study

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