What question did this study set out to answer?

The aim is to understand what T cells recognize on B cells by profiling the MHCII immunopeptidome of germinal center B cells.

What T cells see in B cells: Defining the immunopeptidome of germinal center B cells 2265788

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Randomized trial defines T cell recognition of B cell peptides, suggesting implications for immune response regulation.

The aim is to understand what T cells recognize on B cells by profiling the MHCII immunopeptidome of germinal center B cells.
Profiles peptides on MHCII using mass spectrometry and antibody techniques.
Utilizes pan-MHCII antibodies for complex pull-down and analysis of eluted peptide fractions.
Maps peptides back to parental proteins to understand the antigenic landscape.
Late germinal center B cells present a different set of peptides from self-sources compared to early cells.
The evolving peptide landscape influences the interaction ratio of helper and regulatory T cells.
This project will provide a longitudinal map of GC B cell immunopeptidome.

Chopde et al. (2026) studied this question.

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