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Evaluate GMP reagents for NK cell isolation, activation, and expansion to enhance adoptive cell therapy.

Human NK Cell Enrichment and Expansion Using Defined GMP Reagents: Functional and Phenotypic Outcomes 2252995

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Randomized trial evaluates NK cell activation and expansion in leukopak mononuclear cells, indicating effective therapeutic application.

Evaluate GMP reagents for NK cell isolation, activation, and expansion to enhance adoptive cell therapy.
NK cells isolated from leukopak mononuclear cells via positive and negative selection methods.
NK cells activated and expanded for 14 days in vitro using GMP-grade recombinant human IL-2 and IL-15.
Both isolation methods produced highly viable NK cell populations with varying purity.
Functional analyses indicated effective cytokine secretion post-expansion with strong target cell killing capacity.

Scorza et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial evaluates NK cell activation and expansion in leukopak mononuclear cells, indicating effective therapeutic application.

Evaluate GMP reagents for NK cell isolation, activation, and expansion to enhance adoptive cell therapy.
NK cells isolated from leukopak mononuclear cells via positive and negative selection methods.
NK cells activated and expanded for 14 days in vitro using GMP-grade recombinant human IL-2 and IL-15.
Both isolation methods produced highly viable NK cell populations with varying purity.
Functional analyses indicated effective cytokine secretion post-expansion with strong target cell killing capacity.

Scorza et al. (2026) studied this question.

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