Key result
In guinea pig papillary muscle, the reversed frequency-dependent APD-prolonging effect of dofetilide was reduced by diltiazem and aggravated by Bay K 8644 or dihydroouabain.
Reducing L-type calcium current attenuates the reversed frequency-dependent action potential prolongation of dofetilide, suggesting a more favorable electrophysiological profile.
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Suggests L-type Ca modulation alters dofetilide APD effects in vitro; leaves open clinical relevance for antiarrhythmic use.
Gjini et al. (1998) studied this question. Dofetilide with L-type calcium current modulators vs. Dofetilide alone was evaluated on Action-potential duration (APD) prolonging effect (deltaAPD). In guinea pig papillary muscle, the reversed frequency-dependent APD-prolonging effect of dofetilide was reduced by diltiazem and aggravated by Bay K 8644 or dihydroouabain.
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