Key result
Adipose tissue functions as an active endocrine organ, secreting adipokines and lipokines that communicate with distant organs to regulate systemic insulin sensitivity and vascular function.
Adipose tissue acts as an active endocrine organ, secreting adipokines and lipokines that regulate insulin sensitivity and vascular function in distant organs, providing a mechanistic link between obesity and metabolic/vascular dysfunction.
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Suggests adipose-derived signals drive obesity-related cardiometabolic risk; leaves open validation of adipokine-targeted therapies in trials.
Zhang et al. (2010) conducted a review in Obesity and insulin resistance. Adipose tissue functions as an active endocrine organ, secreting adipokines and lipokines that communicate with distant organs to regulate systemic insulin sensitivity and vascular function.
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