Key result
Changes in NT-proBNP levels during treatment correlated with changes in right ventricular end-diastolic volume index (r=0.59), mass index (r=0.62), and ejection fraction (r=-0.81).
Why the study?
Does NT-proBNP reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment?
Observational (n=30)
Does NT-proBNP reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment?
Effect estimate: r = 0.59 (RVEDVI), r = 0.62 (RV mass index), r = -0.81 (RVEF)
Changes in NT-proBNP over time reliably reflect changes in right ventricular structure and function, including dilatation, hypertrophy, and systolic function deterioration, in patients with pulmonary hypertension.
NT-proBNP changes may track RV remodeling in treated PH; hypothesis-generating and requires prospective validation.
The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment. The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up. There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r = -0.81). N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.
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Gan et al. (2006) conducted an observational in Pulmonary hypertension (n=30). Changes in NT-proBNP levels was evaluated on Correlation between relative changes in NT-proBNP and right ventricular parameters (r = 0.59 (RVEDVI), r = 0.62 (RV mass index), r = -0.81 (RVEF)). Changes in NT-proBNP levels during treatment correlated with changes in right ventricular end-diastolic volume index (r=0.59), mass index (r=0.62), and ejection fraction (r=-0.81).
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