July 1, 1981Pacing and Clinical Electrophysiology
An Evaluation of Long‐term Stimulation Thresholds by Measurement of Chronic Strength Duration Curves
Key result
Chronic strength duration curves were shifted upward and to the right of acute curves, suggesting that variable pulse width exceeding 1 ms may not significantly reduce stimulation thresholds.
Why the study?
How do chronic strength duration curves compare to acute strength duration curves in patients with cardiac pacemakers?
Population
47 patients undergoing pacemaker generator replacement and 19 patients at the time of initial pacemaker…
Comparison
Measurement of chronic strength duration curves… vs Acute strength duration curves measured at the…
Design
Cohort
Authors
Discussion
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Implication
Caution advised against assuming benefit from longer pulse widths in chronic implants; extends acute observations but remains hypothesis-generating.
Study Design
Type
Observational (n=66)
Structured PICO
How do chronic strength duration curves compare to acute strength duration curves in patients with cardiac pacemakers?
P
Population
66 patients undergoing cardiac pacemaker generator replacement (n=47) or initial implantation (n=19) to evaluate strength duration curves.
E
Exposure
Measurement of chronic strength duration curves at the time of generator replacement.
C
Comparator
Acute strength duration curves measured at the time of initial implantation.
O
Outcome
Cardiac stimulation thresholds as a function of impulse duration (strength duration curve shape and shift).surrogate
Chronic pacemaker stimulation thresholds are shifted upward and to the right compared to acute thresholds, suggesting that increasing pulse width beyond 1 ms may not significantly reduce stimulation thresholds.
Cite This Study
Hynes et al. (1981) conducted an observational in Cardiac pacemaker therapy (n=66). Chronic pacemaker leads (at generator replacement) vs. Acute pacemaker leads (at initial implantation) was evaluated on Strength duration curves (stimulation thresholds as a function of impulse duration). Chronic strength duration curves were shifted upward and to the right of acute curves, suggesting that variable pulse width exceeding 1 ms may not significantly reduce stimulation thresholds.