Key result
Pericardial inflammatory mediators are implicated in the pathophysiology of postoperative atrial fibrillation in cardiac surgery patients, representing potential targets to reduce its incidence.
Why the study?
Postoperative atrial fibrillation is a common complication after cardiac surgery, and recent evidence shows the pericardial space contains inflammatory mediators that could trigger it.
Highlights the potential role of pericardial inflammatory mediators in the pathophysiology of postoperative atrial fibrillation, suggesting future therapeutic targets.
Hypothesis-generating for pericardial anti-inflammatory strategies in cardiac surgery; randomized trials needed before practice change.
Postoperative atrial fibrillation (POAF) is a common dysrhythmia that affects a significant number of patients undergoing cardiac surgery. Many studies aim to better understand this complex postsurgical complication by analysing circulating biomarkers in patients who develop POAF. More recently, the pericardial space was shown to contain inflammatory mediators that could trigger POAF. In this review we summarise recent studies that examine the immune mediators present in the pericardial space and their potential implications for the pathophysiology of POAF in cardiac surgery patients. Ongoing research in this area should better delineate the multifactorial etiology of POAF, where specific markers may be targeted to reduce the incidence of POAF and improve outcomes for this patient population.
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Hassanabad et al. (2023) conducted a review in Postoperative atrial fibrillation (POAF) in cardiac surgery patients. Pericardial inflammatory mediators was evaluated. Pericardial inflammatory mediators are implicated in the pathophysiology of postoperative atrial fibrillation in cardiac surgery patients, representing potential targets to reduce its incidence.
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