November 1, 1997ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)
Cardiac Type-1 Angiotensin II Receptor Status in Deoxycorticosterone Acetate–Salt Hypertension in Rats
Key result
DOCA-salt hypertension in rats was associated with a 1.8-fold increase in Ang II-specific binding and enhanced intracellular calcium responses in ventricular myocytes compared to controls.
Population
Adult ventricular myocytes and fibroblasts from experimentally induced hypertensive deoxycorticosterone…
Comparison
4-week DOCA-salt treatment vs Unilaterally nephrectomized (Uni-Nx) control rats
Design
Preclinical
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
Does not inform clinical hypertension care; leaves open Ang II receptor-Ca2+ mechanisms in cardiac cells.
Structured PICO
P
Population
Adult Sprague-Dawley rats subjected to 4-week DOCA-salt treatment to induce hypertension, compared to unilaterally nephrectomized controls.
I
Intervention
4-week DOCA-salt treatment
C
Comparator
Unilaterally nephrectomized (Uni-Nx) control rats
O
Outcome
Angiotensin II (Ang II) receptor density and intracellular Ca2+ concentrationsurrogate
Main Result
Effect estimate: 1.8-fold increase
DOCA-salt hypertension increases AT1 receptor density and intracellular calcium responses specifically in ventricular myocytes, highlighting cell-specific Ang II signaling in cardiac hypertrophy.
Cite This Study
Fareh et al. (1997) studied Deoxycorticosterone acetate (DOCA)-salt hypertension. Deoxycorticosterone acetate (DOCA)-salt treatment vs. Unilaterally nephrectomized (Uni-Nx) control rats was evaluated on Angiotensin II receptor density and intracellular Ca2+ concentration in cardiac cells (1.8-fold increase). DOCA-salt hypertension in rats was associated with a 1.8-fold increase in Ang II-specific binding and enhanced intracellular calcium responses in ventricular myocytes compared to controls.