Key result
The G allele of the ADRB2 rs1042714 polymorphism was associated with a decreased risk of developing hypertriglyceridemia (OR 0.72) in a Kazakh population.
Why the study?
The study was conducted to determine the association between hypertriglyceridemia and polymorphisms in the ADRB2 and LPL genes.
Are LPL rs328 and ADRB2 rs1042714 gene polymorphisms associated with the risk of developing hypertriglyceridemia?
Case-Control (n=460)
Are LPL rs328 and ADRB2 rs1042714 gene polymorphisms associated with the risk of developing hypertriglyceridemia?
Odds Ratio: 0.72 (95% CI 0.52–0.98)
p-value: p=0.038
The ADRB2 rs1042714 G allele is associated with a decreased risk of hypertriglyceridemia, whereas LPL rs328 polymorphisms showed no significant association.
Hypertriglyceridemia may associate with ADRB2/LPL polymorphisms; hypothesis-generating, requires prospective validation before clinical use.
The measurement of lipid metabolism indicators is an integral part of the assessment and control of the risk of developing atherosclerosis and cardiovascular diseases. Triglyceride levels are of particular importance as they are the main component of fat cells. The objective of the present study was to determine the association between hypertriglyceridemia and the polymorphisms of genes of β2‑adrenergic receptor (ADRB2) and lipoprotein lipase (LPL). The present study was a case‑control study. A total of 460 subjects participated in the study. Plasma total cholesterol, triglyceride, high‑density lipoprotein, low‑density lipoprotein, apolipoprotein B and apolipoprotein A1 levels were examined in all subjects. Quantitative PCR was performed to detect the LPL rs328, ADRB2 rs1042714 gene polymorphisms, which were found to be previously associated with susceptibility to obesity‑related phenotypes and dyslipidemia. The results revealed a significant association of the rs1042714 polymorphism of the ADRB2 gene with triglyceride levels (P=0.04). The C allele and the association of the C/C and C/G genotypes of the rs1042714 polymorphism of the ADBR2 gene were more frequent in individuals with elevated triglyceride levels compared with those with normal triglyceride levels. The G allele and the G/G genotype of the rs1042714 polymorphism of the ADBR2 gene were protective and were associated with a reduced risk of developing hypertriglyceridemia (odds ratio, 0.72; 95% CI, 0.52‑0.98 P=0.038). The LPL rs328 alleles were not associated with a significantly increased risk of developing hypertriglyceridemia. On the whole, the findings of the present study indicated that the ADRB2 rs1042714 allele G was associated with a decreased risk of developing hypertriglyceridemia. Polymorphisms of the LPL rs328 gene were not associated with hypertriglyceridemia and haplotype combinations were not associated with hypertriglyceridemia.
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А.Т. et al. (2023) conducted a case-control in Hypertriglyceridemia (n=460). ADRB2 rs1042714 polymorphism (G allele) vs. C allele / C/C genotype was evaluated on Risk of developing hypertriglyceridemia (OR 0.72, 95% CI 0.52-0.98, p=0.038). The G allele of the ADRB2 rs1042714 polymorphism was associated with a decreased risk of developing hypertriglyceridemia (OR 0.72) in a Kazakh population.
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