Key result
Para-aortic adipose tissue thickness measured by transthoracic echocardiography was significantly associated with ascending aortic dilatation (OR 3.005).
Why the study?
Studies using CT and MRI show higher para-aortic adipose tissue in aortic aneurysm, but PAT had not been evaluated using transthoracic echocardiography to investigate its relationship with ascending aortic width.
Is para-aortic adipose tissue measured by transthoracic echocardiography associated with ascending aortic dilatation?
Cross-Sectional (n=321)
No
Is para-aortic adipose tissue measured by transthoracic echocardiography associated with ascending aortic dilatation?
Odds Ratio: 3.005 (95% CI 1.445–6.251)
p-value: p=<0.0001
Para-aortic adipose tissue measured by transthoracic echocardiography is significantly associated with ascending aortic dilatation and may serve as a follow-up parameter for aortic aneurysm risk.
May aid aortic dilatation risk stratification on routine echo; hypothesis-generating and requires prospective validation before practice change.
Purpose: Para-aortic adipose tissue (PAT) is the local adipose tissue that externally surrounds the aorta. It contributes significantly to aortic atherosclerosis and enlargement. Studies conducted with computed tomography and magnetic resonance have shown that individuals with aortic aneurysm had more PAT than healthy individuals. In this study, we measured PAT for the first time using transthoracic echocardiography (TTE).The aim of this study is to investigate the possible relationship of TTE measured PAT with ascending aortic width. Methods: PAT was defined as the hypoechoic space in front of ascending aortic 2 cm above the sinotubular junction at the end of the systole. Patients were divided into 2 groups according to the presence of dilatation in the ascending aorta using Roman's classification (aortic size index, ASI). ASI of less than 21 was considered no aortic dilation and an ASI of 21mm/m2 or greater was considered to have aortic dilation. Results : A total of 321 unselected patients were divided into the ascending aortic dilatation (AAD) group (n=96) and the normal ascending aorta diameter group (n=225 patients). PAT was significantly higher in the AAD group compared with the non-ADD group (0.9 (0.48) vs. 0.7 (0.91) mm, p < 0.0001). Univariate and multivariate logistic regression analysis revealed that PAT (OR: 3.005, 95%CI (1.445–6.251)) were significantly associated with AAD. Conclusion: Our results showed an association between PAT measured by transthoracic echocardiography and ascending aorta width. PAT appears to be an important follow-up parameter in patients at risk of developing aortic aneurysm.
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Adar et al. (2022) conducted a cross-sectional in Ascending aortic dilatation (n=321). Para-aortic adipose tissue (PAT) vs. Lower PAT thickness was evaluated on Ascending aortic dilatation (AAD) (OR 3.005, 95% CI 1.445-6.251, p=<0.0001). Para-aortic adipose tissue thickness measured by transthoracic echocardiography was significantly associated with ascending aortic dilatation (OR 3.005).
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