Key result
Exercise training improves obesity-induced arterial dysfunction by reducing PVAT inflammation and oxidative stress.
Why the study?
Does exercise training improve arterial health via perivascular adipose tissue in obese populations?
Does exercise training improve arterial health via perivascular adipose tissue in obese populations?
Exercise training provides a novel pathway to improve arterial health in obese populations by beneficially affecting perivascular adipose tissue.
Exercise may improve arterial function via perivascular adipose tissue in obesity; hypothesis-generating and requires prospective trials before clinical adoption.
Adipose tissue and arterial dysfunction are common in the obese state. Perivascular adipose tissue (PVAT) plays an important role in mediating arterial health, and with obesity, the PVAT dysfunction negatively affects arterial health. Exercise training exerts direct and beneficial effects on PVAT, providing an additional and novel pathway by which exercise can improve arterial health in diseased populations.
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Boateng et al. (2021) conducted a review in Obesity and arterial dysfunction. Exercise training was evaluated. Exercise training exerts beneficial effects on perivascular adipose tissue phenotype by reducing inflammation and oxidative stress, thereby improving obesity-induced arterial dysfunction.
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