Key result
Exercise in obese mice restores PVAT anti-contractile function and normalizes blood pressure without weight loss.
Why the study?
In obesity, autonomic dysfunction occurs and may cause loss of perivascular adipose tissue function and vascular disease; whether exercise can restore this function was investigated.
Does exercise restore perivascular adipose tissue anti-contractile function in a mouse model of diet-induced obesity?
Does exercise restore perivascular adipose tissue anti-contractile function in a mouse model of diet-induced obesity?
p-value: p=<0.0001
Exercise restores the anti-contractile function of perivascular adipose tissue in obesity by reducing inflammation and upregulating β3-adrenoceptors, independent of weight loss.
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Supports exercise benefits beyond weight loss in obese mice; hypothesis-generating for human perivascular adipose tissue function.
Saxton et al. (2021) studied Obesity and metabolic syndrome (n=102). Exercise (forced swim training) vs. Sedentary obese mice was evaluated on Vascular contractility to electrical field stimulation (PVAT anti-contractile effect) (p=<0.0001). Exercise training in obese mice restored perivascular adipose tissue anti-contractile function and normalized blood pressure and glucose levels independent of weight loss.
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