What question did this study set out to answer?

This analysis aims to validate the prognostic significance of the Ki-67 staining index in locally advanced prostate cancer treated with radiotherapy.

June 15, 2004Clinical Cancer Research

Ki-67 Staining Index Predicts Distant Metastasis and Survival in Locally Advanced Prostate Cancer Treated With Radiotherapy

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This analysis aims to validate the prognostic significance of the Ki-67 staining index in locally advanced prostate cancer treated with radiotherapy.
Analysis of Ki-67 SI in diagnostic material from 108 patients treated with radiotherapy.
Patients received either external beam radiotherapy or short-term androgen deprivation plus EBRT.
Follow-up duration was 9 years for surviving patients.
The 5-year risk of distant metastasis was 50.8% for Ki-67 SI >3.5% versus 13.5% for SI <=3.5%, P=0.0005.
The 5-year disease-specific survival rates were 67.7% for Ki-67 SI >3.5% versus 97.3% for SI <=3.5%, P=0.0039.
No significant association was found between Ki-67 SI and overall survival.

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Implication

Randomized trial validates Ki-67 staining index as a predictor of distant metastasis and survival in locally advanced prostate cancer, suggesting its use as a clinical biomarker.

Cite This Study

Li et al. (2004) studied this question.

synapsesocial.com/papers/6a6b4b2347a1bfb288f316da https://doi.org/10.1158/1078-0432.ccr-1052-03

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Implication

Randomized trial validates Ki-67 staining index as a predictor of distant metastasis and survival in locally advanced prostate cancer, suggesting its use as a clinical biomarker.

Ki-67 Staining Index Predicts Distant Metastasis and Survival in Locally Advanced Prostate Cancer Treated With Radiotherapy

Key Points

Discussion

Implication

Cite This Study

Ki-67 Staining Index Predicts Distant Metastasis and Survival in Locally Advanced Prostate Cancer Treated With Radiotherapy

Key Points

Discussion

Implication

Cite This Study

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