Key result
Brefeldin A inhibits poliovirus RNA replication in a cell-free system, likely by targeting ARF (ADP-ribosylation factor) activity required for secretory vesicle synthesis.
Why the study?
Does Brefeldin A inhibit poliovirus RNA replication in a cell-free system?
Population
Cell-free poliovirus translation, replication, and encapsidation system
Design
Preclinical
Authors
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Brefeldin A may support ARF as an antiviral target; leaves open translation from cell-free systems to clinical use.
Does Brefeldin A inhibit poliovirus RNA replication in a cell-free system?
Brefeldin A inhibits poliovirus RNA replication in a cell-free system, suggesting a requirement for ARF activity in viral replication.
Cuconati et al. (1998) studied Poliovirus infection (in vitro). Brefeldin A was evaluated on Poliovirus RNA replication in a cell-free system. Brefeldin A inhibits poliovirus RNA replication in a cell-free system, likely by targeting ARF (ADP-ribosylation factor) activity required for secretory vesicle synthesis.
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