Key result
Acute myocardial infarction was associated with 20% more GPIIb-IIIa complexes on platelets and 7% greater platelet size compared with controls.
Why the study?
Are platelet GPIIb-IIIa complex numbers and platelet size increased in patients immediately following acute myocardial infarction compared to controls?
Population
28 subjects: patients immediately following acute myocardial infarction (AMI) (n=14) and controls (n=14).
Design
Case-control
Authors
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May indicate heightened platelet reactivity in AMI; leaves open prognostic value and therapeutic implications.
Case-Control (n=28)
Are platelet GPIIb-IIIa complex numbers and platelet size increased in patients immediately following acute myocardial infarction compared to controls?
Effect estimate: 20% more
Patients with acute myocardial infarction have larger platelets with increased GPIIb-IIIa complexes, suggesting a potential causal relationship between these highly reactive platelets and AMI.
Giles et al. (1994) conducted a case-control in Acute myocardial infarction (n=28). Acute myocardial infarction vs. Controls was evaluated on Relative number of GPIIb-IIIa complexes on platelets (20% more). Acute myocardial infarction was associated with 20% more GPIIb-IIIa complexes on platelets and 7% greater platelet size compared with controls.
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