Key result
Alcohol ablation of the left posterior papillary muscle significantly reduced ventricular fibrillation inducibility to 11.9% post-ablation compared to 92.9% in controls (P=0.001).
Why the study?
Does alcohol ablation of the posterior papillary muscle reduce ventricular fibrillation inducibility in normal intact swine hearts?
Population
12 anesthetized normal intact swine
Comparison
Chemical ablation via injection of dehydrated… vs Chemical ablation via injection of dehydrated…
Design
Preclinical
Authors
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May guide preclinical VF substrate targeting; leaves open translation to human arrhythmia management.
Does alcohol ablation of the posterior papillary muscle reduce ventricular fibrillation inducibility in normal intact swine hearts?
Absolute Event Rate: 11.9% vs 92.9%
p-value: p=0.001
Alcohol ablation of the left posterior papillary muscle effectively reduces ventricular fibrillation inducibility in a swine model without compromising mitral valve function.
Guo et al. (2010) studied Ventricular fibrillation (n=12). Chemical ablation via injection of dehydrated alcohol into the base of the posterior papillary muscle vs. Chemical ablation via injection of dehydrated alcohol into the anterior wall was evaluated on Ventricular fibrillation inducibility post-ablation (p=0.001). Alcohol ablation of the left posterior papillary muscle significantly reduced ventricular fibrillation inducibility to 11.9% post-ablation compared to 92.9% in controls (P=0.001).
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