What question did this study set out to answer?

To understand the interactions of tick-borne encephalitis virus capsid proteins with membranes and RNA.

Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein

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This research investigates how capsid protein binds to membranes and recruits RNA in a viral model, suggesting a role in nucleocapsid assembly.

To understand the interactions of tick-borne encephalitis virus capsid proteins with membranes and RNA.
Investigated wild-type and truncated capsid proteins using biophysical methods and model membrane systems.
Analyzed membrane interactions and RNA recruitment by in vitro experiments.
Used mass spectrometry to confirm the presence of negatively-charged lipids in purified virions.
Capsid protein binds to membranes through electrostatic interactions with negatively-charged lipids.
Membrane insertion of capsid protein is observed following initial binding.
RNA recruitment to membrane-bound capsid protein is confirmed, indicating a link to nucleocapsid assembly.

Pulkkinen et al. (2023) studied this question.

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This research investigates how capsid protein binds to membranes and recruits RNA in a viral model, suggesting a role in nucleocapsid assembly.