Key result
A high Ang-2/1 mRNA ratio in hepatocellular carcinoma was associated with tumor portal vein invasion, larger tumor diameter, higher microvessel density, and significantly poorer survival time.
Population
46 patients with hepatocellular carcinoma (HCC) who underwent surgical resection
Design
Cohort
Authors
Loading...
Angiopoietin/Tie-2 expression patterns in HCC specimens leave open their role in tumor angiogenesis; prospective studies needed before therapeutic targeting.
Observational (n=46)
Increased expression of Ang-2/1 in the presence of VEGF is associated with tumor angiogenesis, progression, and poorer survival in human hepatocellular carcinoma.
Mitsuhashi et al. (2003) conducted an observational in Human hepatocellular carcinoma (HCC) (n=46). High Ang-2/1 mRNA ratio vs. Low Ang-2/1 mRNA ratio was evaluated on Survival time and tumor progression (portal vein invasion, tumor diameter, microvessel density). A high Ang-2/1 mRNA ratio in hepatocellular carcinoma was associated with tumor portal vein invasion, larger tumor diameter, higher microvessel density, and significantly poorer survival time.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: