Why the study?
Does sTie2 expression suppress tumorigenicity and neovascularization in hepatocellular carcinoma?
Does sTie2 expression suppress tumorigenicity and neovascularization in hepatocellular carcinoma?
Inhibition of the Ang/Tie2 signal transduction cascade via sTie2 expression suppresses HCC neovascularization and tumorigenicity, suggesting a potential therapeutic target.
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Should not change HCC practice; animal data leave open Tie2 inhibition as a therapeutic target.
Tanaka et al. (2002) studied this question.
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