Key result
In a porcine model, [(11)C]KR31173 PET imaging showed no significant changes in radioligand binding parameters caused by ischemia-reperfusion, with significant correlations between parameters (r > 0.9).
A parallel connectivity compartmental model successfully quantifies the kinetics of the AT1R PET radioligand [11C]KR31173, and simple radioligand retention may be adequate for estimating in vivo binding if an arterial input function is unavailable.
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Supports simplified retention metrics for AT1R PET kidney quantification; leaves open clinical translation pending human studies.
Gülaldı et al. (2013) studied Renal ischemia followed by reperfusion (n=10). [(11)C]KR31173 PET imaging vs. Controls (no ischemia-reperfusion) was evaluated on Radioligand binding parameters and correlations between rate constants and binding parameters. In a porcine model, [(11)C]KR31173 PET imaging showed no significant changes in radioligand binding parameters caused by ischemia-reperfusion, with significant correlations between parameters (r > 0.9).
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