Key result
In a rat model of myocardial ischemia-reperfusion injury, oral valsartan partially blocked AT1R tracer uptake (infarct-to-remote ratio 2.07 vs 2.94 untreated), whereas enalapril did not.
AT1R-targeted PET imaging can detect transient regional AT1R upregulation after myocardial ischemia-reperfusion injury and monitor the blocking efficacy of ARBs like valsartan.
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AT1R PET may monitor ARB occupancy in infarct models; leaves open human translation and clinical utility.
Higuchi et al. (2010) studied Myocardial ischemia-reperfusion injury (n=47). Valsartan, enalapril, or SK-1080 vs. No treatment was evaluated on Infarct-to-remote ratio of (11)C-KR31173 uptake. In a rat model of myocardial ischemia-reperfusion injury, oral valsartan partially blocked AT1R tracer uptake (infarct-to-remote ratio 2.07 vs 2.94 untreated), whereas enalapril did not.
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