Key result
MassTag polymerase chain reaction identified pathogens in 26 of 79 (32.9%) previously negative samples from patients with influenza-like illness, primarily revealing rhinoviruses.
Why the study?
Does MassTag polymerase chain reaction improve the detection of respiratory pathogens in patients with influenza-like illness who test negative by standard methods?
Population
79 samples from patients with influenza-like illness in New York State during winter 2004 that previously…
Comparison
MassTag polymerase chain reaction vs Standard molecular methods and virus culture
Design
Other
Authors
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Caution against routine ILI diagnostic adoption; leaves open utility pending prospective validation.
Observational (n=79)
Does MassTag polymerase chain reaction improve the detection of respiratory pathogens in patients with influenza-like illness who test negative by standard methods?
MassTag PCR is a useful multiplex diagnostic tool that can identify respiratory pathogens, such as novel rhinovirus clades, in samples that test negative by standard methods.
Lamson et al. (2006) conducted an observational in Influenza-like illness (n=79). MassTag polymerase chain reaction vs. Standard molecular methods and virus culture was evaluated on Pathogen detection in previously negative samples. MassTag polymerase chain reaction identified pathogens in 26 of 79 (32.9%) previously negative samples from patients with influenza-like illness, primarily revealing rhinoviruses.
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