Post-infarct evolution of ventricular and myocardial function

Fig. 1. LV geometry with infarct region and border zone a, fiber orientation b and LV mesh c without (left) and with (right) wall thinning. For clarity, the contours of the transmural infarct are depicted on the endocardial surface only. Anterior sites are located in the infarct. Posterior (P), anterior-medial (AM) and anterior-lateral (AL) sites are located in the healthy tissue outside the border zone in both subepicardial and subendocardial layers. In (b), the helix angle \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha _h$$\end{document}αh is plotted in colour

Fig. 2. Pressure over volume plot of simulation REF (red), AMI (blue) and CMI5 (green), CMI100 (yellow), CMI5wt (orange) and CMI5cf (purple)

Fig. 3. Work generated by fibers over the cardiac cycle, according to equation 5, for simulation REF. The figures for simulations AMI, CMI5 and CMI100 show normalized work with respect to the healthy simulation

Fig. 4. Work generated by fibers over the cardiac cycle, according to equation 5, for simulation REF. The figures for simulations CMI5, CMI5wt and CMI5cf show normalized work with respect to the healthy simulation

Fig. 5. Local myofiber mechanics (rows) in 4 subepicardial (a) and subendocardial (b) points (columns). From the top to bottom row, Cauchy stress in fiber direction and logarithmic strain as a function of time and stress–strain loops for a healthy heart, AMI, CMI5 and CMI100. The dotted lines mark the diastolic, isovolumic contraction, systolic and isovolumic relaxation phase, respectively. End-diastole and end-systole are marked with a \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\circ$$\end{document}∘ and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\lozenge$$\end{document}◊ respectively

Fig. 6. Local myofiber mechanics (rows) in 4 subepicardial (a) and subendocardial (b) points (columns). From the top to bottom row, Cauchy stress in fiber direction and logarithmic strain as a function of time and stress–strain loops for a healthy heart, CMI5, CMI5wt and CMI5cf. The dotted lines mark the diastolic, isovolumic contraction, systolic and isovolumic relaxation phase, respectively. End-diastole and end-systole are marked with a \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\circ$$\end{document}∘ and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\lozenge$$\end{document}◊ respectively

Fig. 7. Overview of local metrics as measured subepicardially (a) and subendocardially (b) for the healthy heart, AMI, CMI2, CMI5, CMI10, CMI20 and CMI100. From top to bottom: work density, maximal Cauchy stress, end-diastolic sarcomere length and end-systolic sarcomere length

Fig. 8. Stress–strain loops in 4 points at 60% of the total endo to epicardial distance. At this transmural level, the helix angle equals 0