Key result
High plasma CRP levels (≥1.77 mg/L) were associated with a 1.8-fold increased risk of ischemic heart disease (95% CI 1.2-2.7), particularly in men ≤55 years and for short-term events.
Why the study?
Do high plasma CRP levels predict an increased risk for future IHD in IHD-free middle-aged men?
Cohort (n=2,037)
Do high plasma CRP levels predict an increased risk for future IHD in IHD-free middle-aged men?
Relative Risk: 1.8 (95% CI 1.2–2.7)
Plasma CRP levels may provide independent prognostic information for IHD risk primarily in younger middle-aged men (≤55 years) and for short-term events (≤2 years).
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High CRP may flag short-term IHD risk in men ≤55 years; leaves open incremental value after nonlipid adjustment.
Matteo Pirro (2001) conducted a cohort in Ischemic heart disease risk (n=2,037). High plasma C-reactive protein (CRP) levels (≥1.77 mg/L) vs. Low plasma CRP levels (<1.77 mg/L) was evaluated on First ischemic heart disease (IHD) events (RR 1.8, 95% CI 1.2-2.7). High plasma CRP levels (≥1.77 mg/L) were associated with a 1.8-fold increased risk of ischemic heart disease (95% CI 1.2-2.7), particularly in men ≤55 years and for short-term events.
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