Key result
Elevated baseline CRP links to ~87% higher incident CHD risk in older adults.
Why the study?
The association between systemic C-reactive protein and incident coronary heart disease in community-dwelling elderly people was assessed to clarify its predictive value.
Does elevated baseline CRP predict incident coronary heart disease in community-dwelling elderly people?
Cohort (n=9,294)
Yes
Does elevated baseline CRP predict incident coronary heart disease in community-dwelling elderly people?
Hazard Ratio: 1.87 (95% CI 1.09–3.25)
While elevated CRP is an independent risk marker for incident CHD in the elderly, it does not add predictive value beyond traditional cardiovascular risk factors.
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CRP independently marks CHD risk in elderly adults but adds no predictive value; leaves open its role in geriatric risk stratification.
Straczek et al. (2009) conducted a cohort in Coronary heart disease (n=9,294). Systemic C-reactive protein (CRP) level 3.0 to 10.0 mg/L vs. CRP level less than 1.0 mg/L was evaluated on Incident coronary heart disease (CHD) (HR 1.87, 95% CI 1.09-3.25). In community-dwelling older adults, a baseline CRP level of 3.0 to 10.0 mg/L was independently associated with an increased risk of incident coronary heart disease (HR 1.87; 95% CI 1.09-3.25).
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