Key result
Resident fibroblast lineages originating from the epicardium and endocardium, rather than de novo activation or hematopoietic cells, mediate pressure overload-induced cardiac fibrosis in murine models.
Population
Murine hearts subjected to aortic banding (pressure overload hypertrophy)
Design
Editorial
Authors
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Demonstrates that cardiac fibroblasts in pressure overload hypertrophy originate from resident epicardial and endocardial fibroblasts, highlighting new targets for cardiac therapies.
Demonstrates that cardiac fibroblasts in pressure overload hypertrophy originate from resident epicardial and endocardial fibroblasts, highlighting new targets for cardiac therapies.
Nenad Bursac (2014) conducted an editorial in Cardiac fibrosis and pressure overload hypertrophy. Resident fibroblast lineages originating from the epicardium and endocardium, rather than de novo activation or hematopoietic cells, mediate pressure overload-induced cardiac fibrosis in murine models.
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