Why the study?
What is the cellular origin of cardiac fibroblasts in pressure overload-induced cardiac fibrosis?
What is the cellular origin of cardiac fibroblasts in pressure overload-induced cardiac fibrosis?
Cardiac fibrosis following pressure overload is mediated by the proliferation of resident fibroblast lineages rather than endothelial-to-mesenchymal transition or circulating progenitors, suggesting therapeutic strategies should target these endogenous populations.
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Resident fibroblast lineages should guide antifibrotic targeting; leaves open translation from murine models to human pressure-overload fibrosis.
Moore‐Morris et al. (2014) studied this question.
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