Key result
High dietary vitamin K intake was associated with a lower risk of having a time in target range <60% (OR 0.43; 95% CI 0.19-0.95) compared with the lowest third of intake.
Why the study?
Does high dietary Vitamin K intake improve INR stability and reduce INR testing frequency in new warfarin users?
Population
245 new warfarin users
Comparison
High dietary Vitamin K intake vs Low dietary Vitamin K intake (lowest third)
Design
Cohort
Follow-up
3-12 months after initiation of warfarin
Authors
Loading...
May support considering vitamin K intake for INR stability in new warfarin users; hypothesis-generating, needs randomized confirmation.
Cohort (n=245)
Does high dietary Vitamin K intake improve INR stability and reduce INR testing frequency in new warfarin users?
Odds Ratio: 0.43 (95% CI 0.19–0.95)
High dietary Vitamin K intake is associated with improved INR stability and fewer required INR tests in new warfarin users, though it requires a moderately higher warfarin stabilization dose.
Leblanc et al. (2015) conducted a cohort in New warfarin users (n=245). High dietary Vitamin K intake (highest third) vs. Lowest third of dietary Vitamin K intake was evaluated on Time in target range (TTR) <60% (OR 0.43, 95% CI 0.19-0.95). High dietary vitamin K intake was associated with a lower risk of having a time in target range <60% (OR 0.43; 95% CI 0.19-0.95) compared with the lowest third of intake.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: