Key result
Each 100 microg increase in daily dietary vitamin K intake averaged over 4 days reduced the INR by 0.2, suggesting consistent intake could reduce intrapatient variability in anticoagulation response.
Why the study?
Does dietary vitamin K intake influence intra-individual variability in anticoagulant response to warfarin in patients on stably controlled warfarin therapy?
Population
n=53 patients on warfarin therapy who had stably controlled anticoagulation
Design
Cohort
Follow-up
4 weeks
Authors
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May explain INR fluctuations via vitamin K variation; leaves open whether dietary standardization improves stability.
Observational (n=53)
Does dietary vitamin K intake influence intra-individual variability in anticoagulant response to warfarin in patients on stably controlled warfarin therapy?
Effect estimate: INR reduced by 0.2 per 100 microg increase in daily dietary vitamin K
Variations in daily dietary vitamin K intake significantly affect intra-patient INR response, suggesting that consistent vitamin K intake could improve the safety and stability of warfarin therapy.
Khan et al. (2004) conducted an observational in Stably controlled anticoagulation on warfarin therapy (n=53). Dietary intake of vitamin K was evaluated on International normalized ratio (INR) (INR reduced by 0.2 per 100 microg increase in daily dietary vitamin K). Each 100 microg increase in daily dietary vitamin K intake averaged over 4 days reduced the INR by 0.2, suggesting consistent intake could reduce intrapatient variability in anticoagulation response.
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