Key result
Obesity is associated with higher blood pressure, increased vasoconstrictors (angiotensin II, ET-1), and decreased vasodilators (BNP, cGMP), independent of age, gender, and race.
Why the study?
Is obesity associated with altered levels of vasoactive mediators and higher blood pressure?
Observational
Is obesity associated with altered levels of vasoactive mediators and higher blood pressure?
Obesity contributes to hypertension partly through the alteration of vasoactive mediators, specifically by increasing vasoconstrictors and decreasing vasodilators.
Obesity may promote hypertension via vasoactive imbalance; cross-sectional data are hypothesis-generating and require prospective confirmation before guiding practice.
Our data show that obesity, especially morbid obesity, is associated with higher blood pressure levels and increases angiotensin II and endotherlin-1 (ET-1) (vasoconstrictors) and lower levels BNP and cGMP (vasodilators) and that systolic blood pressure variability can be partly explained by levels of angiotensin II, aldosterone, renin, and ET-1. The effect of these mediators on blood pressure is in addition to the effects of other known factors related to age, male gender, and AA race.
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Ghanim et al. (2023) conducted an observational in Obesity. Obesity was evaluated on Blood pressure levels and vasoactive mediators. Obesity is associated with higher blood pressure, increased vasoconstrictors (angiotensin II, ET-1), and decreased vasodilators (BNP, cGMP), independent of age, gender, and race.
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