Key result
Breast cancer patients aged 30 to 64 years had a mildly increased risk of cardiovascular mortality compared to the general female population (IRR 1.06), peaking within the first month after diagnosis.
Why the study?
To investigate the risk of cardiovascular disease mortality in breast cancer patients compared with the general female population.
Does a diagnosis of breast cancer increase the risk of cardiovascular disease mortality in women compared to the general female population?
Cohort (n=924,439)
Does a diagnosis of breast cancer increase the risk of cardiovascular disease mortality in women compared to the general female population?
Relative Risk: 1.06 (95% CI 1.03–1.1)
Absolute Event Rate: 0.11% vs 0.07%
Breast cancer survivors, particularly younger women and those in the first month post-diagnosis, have a significantly elevated risk of cardiovascular mortality compared to the general female population.
May warrant early CV monitoring in younger patients; leaves open causality and optimal interventions.
Aims: To investigate the risk of cardiovascular disease (CVD) mortality in breast cancer patients compared with the general female population. Methods: 30 years and diagnosed during 1990-2016 as well as the aggregated general female population in the US were included. Using multivariable Poisson regression, we calculated incidence rate ratios (IRRs) of CVD mortality among female breast cancer patients compared with the female population. Results: The risk of CVD mortality was mildly increased among breast cancer patients at the age of follow-up 30-64 years (IRR 1.06, 95% confidence interval [CI] 1.03-1.10) compared with the general population. This growth of risk reached its peak within the first month after diagnosis (IRR 3.33, 95% CI 2.84-3.91) and was mainly activated by diseases of the heart (IRR 1.11, 95% CI 1.07-1.15). The elevation was greatest in survivors at the age of follow up 30-34 years (IRR 3.50, 95% CI 1.75-7.01). Conclusions: Clinicians should provide risk mitigation strategies with early monitoring of CVD mortality for breast cancer survivors, especially those who were young or with aggressive tumor stage.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2022) conducted a cohort in Breast cancer (n=924,439). Breast cancer vs. General female population was evaluated on Cardiovascular disease mortality (age 30-64 years) (IRR 1.06, 95% CI 1.03-1.10). Breast cancer patients aged 30 to 64 years had a mildly increased risk of cardiovascular mortality compared to the general female population (IRR 1.06), peaking within the first month after diagnosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: