Key result
Mutagenesis of the RGD motif in human parechovirus 1 VP1 demonstrated that the motif is critical for viral infectivity, with specific mutations proving lethal to the virus.
The RGD motif in human parechovirus 1 VP1 is critical for viral infectivity, likely through integrin interaction.
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RGD motif may guide parechovirus entry inhibitor development; leaves open translation to human infection models.
Boonyakiat et al. (2001) studied Human Parechovirus 1. Mutagenesis of the RGD motif in VP1 was evaluated on Viral infectivity and growth properties. Mutagenesis of the RGD motif in human parechovirus 1 VP1 demonstrated that the motif is critical for viral infectivity, with specific mutations proving lethal to the virus.
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