Key result
Radiotherapy in women with left-sided breast cancer was associated with a significant decrease in aortic distensibility and an increase in hs-CRP compared to no radiotherapy.
Why the study?
Does radiotherapy impair aortic elasticity in women with left-sided erb-2 breast cancer?
Observational (n=105)
Does radiotherapy impair aortic elasticity in women with left-sided erb-2 breast cancer?
Radiotherapy for left-sided breast cancer is associated with dose-dependent impairment of aortic elasticity and increased systemic inflammation, potentially contributing to increased cardiovascular risk.
RT may impair aortic elasticity in left-sided BC; hypothesis-generating, needs prospective confirmation before clinical adoption.
We evaluated the effect of radiotherapy (RT) on the elastic properties of the aorta using echocardiography in patients with breast cancer (BC). A total of 105 women with left-sided epidermal growth factor receptor 2 (erb-2) BC were divided into 2 groups, group 1 with patients who did not receive RT and group 2 with patients who received RT. In all patients, echocardiographic examination and serum high-sensitivity C-reactive protein (hs-CRP) levels were determined. A significant decrease in aortic distensibility (AD) and increase in hs-CRP were seen from group 1 to group 2. The AD was inversely correlated with left ventricle diastolic diameter, systolic blood pressure (SBP), left atrial diameter, age, and RT dose. The AD was significantly related to age, SBP, and RT dose. Increased RT dose is significantly correlated with impaired elastic properties that may contribute to the relation of RT and increased rate of cardiovascular events among patients with BC who received RT.
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Kılıçaslan et al. (2013) conducted an observational in Breast cancer (n=105). Radiotherapy vs. No radiotherapy was evaluated on Aortic distensibility and hs-CRP levels. Radiotherapy in women with left-sided breast cancer was associated with a significant decrease in aortic distensibility and an increase in hs-CRP compared to no radiotherapy.
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