Key result
In a rabbit model of heart failure, in vitro sinus cycle length and responsiveness to acetylcholine increased, suggesting intrinsic sinus node changes cannot explain decreased heart rate variability.
Why the study?
Does intrinsic sinus node function change during the progression of heart failure in a rabbit model?
Population
Rabbit model of heart failure
Comparison
Progression of heart failure vs Control rabbits (for in vitro analysis)
Design
Preclinical
Authors
Loading...
Intrinsic sinus node slowing in failing hearts may predispose to bradyarrhythmias; leaves open relevance to human HF and therapeutic targeting.
Does intrinsic sinus node function change during the progression of heart failure in a rabbit model?
Changes in intrinsic sinus node function during heart failure progression, including increased responsiveness to acetylcholine, cannot explain the decreased heart rate variability and baroreflex sensitivity typically observed in the disease.
Opthof et al. (2000) studied Heart failure (n=27). Heart failure progression vs. Control rabbits was evaluated on Changes in sinus cycle length and occurrence of arrhythmias. In a rabbit model of heart failure, in vitro sinus cycle length and responsiveness to acetylcholine increased, suggesting intrinsic sinus node changes cannot explain decreased heart rate variability.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: